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Can I read Treatment of Missing Values for Multivariate Statistical Analysis of Gel‐based Proteomics Data on EtoBox?
Treatment of Missing Values for Multivariate Statistical Analysis of Gel‐based Proteomics Data by Romina Pedreschi; Maarten L. A. T. M. Hertog; Sebastien C. Carpentier; Jeroen Lammertyn; Johan Robben; Jean‐Paul Noben; Bart Panis; Rony Swennen; Bart M. Nicolaï is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Treatment of Missing Values for Multivariate Statistical Analysis of Gel‐based Proteomics Data about?
## Abstract The presence of missing values in gel‐based proteomics data represents a real challenge if an objective statistical analysis is pursued. Different methods to handle missing values were evaluated and their influence is discussed on the selection of important proteins through multivariate techniques. The evaluated methods consisted of directly dealing with them during the multivariate analysis with the nonlinear estimation by iterative partial least squares (NIPALS) algorithm or imputing them by using either __k__‐nearest neighbor or Bayesian principal component analysis (BPCA) before carrying out the multivariate analysis. These techniques were applied to data obtained from gels stained with classical postrunning dyes and from DIGE gels. Before applying the multivariate techniques, the normality and homoscedasticity assumptions on which parametric tests are based on were tested in order to perform a sound statistical analysis. From the three tested methods to handle missing values in our datasets, BPCA imputation of missing values showed to be the most consistent method.
Who reads Treatment of Missing Values for Multivariate Statistical Analysis of Gel‐based Proteomics Data?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Romina Pedreschi; Maarten L. A. T. M. Hertog; Sebastien C. Carpentier; Jeroen Lammertyn; Johan Robben; Jean‐Paul Noben; Bart Panis; Rony Swennen; Bart M. Nicolaï
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)