Opening book details…
Can I read Safety outcomes of SGLT2i in the heart failure trials: A systematic review and Meta-analysis on EtoBox?
Safety outcomes of SGLT2i in the heart failure trials: A systematic review and Meta-analysis by Ahmed M. Younes; Mahmoud Salem; Ahmed Maraey; Soroush Nomigolzar; Kerry Sewell; Mahmoud Khalil; Ahmed Elzanaty; Ayman Saeyeldin; Moahad Dar is a Medicine article available to read on EtoBox.
What is Safety outcomes of SGLT2i in the heart failure trials: A systematic review and Meta-analysis about?
## Aims: Sodium-glucose co-transporter inhibitors (sglt2i) are emerging as a new treatment for heart failure (hf) after demonstrating favorable clinical outcomes in several randomized controlled trials (rcts). in this meta-analysis, we assessed the safety of sglt2i in the trials that prespecified heart failure in their inclusion criteria. ## Materials and methods: We searched the databases for rcts comparing sglt2i to placebo in heart failure patients. the primary outcome was the incidence of serious adverse events (saes). a sensitivity analysis according to the class of hf was also performed. ## Results: The incidence of saes was significantly lower in the sglt2i group (or, 0.85; 95% ci, 0.77-0.92; p, 0.0002) and saes remained significantly lower after performing the sensitivity analysis (or, 0.82; 95% ci, 0.75-0.89; p, <0.00001). genital infections, urinary tract infections (utis), and hypotension were significantly higher in the sglt2i group. ## Conclusions: Sglt2i remain a safe option for patients with hf with a lower incidence of saes. however, since they increase the risk of genital infection, utis and hypotension, the risks vs benefits in each patient should be weighed when
Who reads Safety outcomes of SGLT2i in the heart failure trials: A systematic review and Meta-analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ahmed M. Younes; Mahmoud Salem; Ahmed Maraey; Soroush Nomigolzar; Kerry Sewell; Mahmoud Khalil; Ahmed Elzanaty; Ayman Saeyeldin; Moahad Dar
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)