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Can I read Interactions Between Mouse Lymphocytes And Borrelia Burgdorferi , The Infectious Agent Of Lyme Disease on EtoBox?
Interactions Between Mouse Lymphocytes And Borrelia Burgdorferi , The Infectious Agent Of Lyme Disease by Dorward, D. is a Materials Science article available to read on EtoBox.
What is Interactions Between Mouse Lymphocytes And Borrelia Burgdorferi , The Infectious Agent Of Lyme Disease about?
Lyme disease is a tick borne, multi-system disorder caused by low density systemic infections with the spirochete __Borrelia burgdorferi__. Without antimicrobial treatment, mammalian infections with these bacteria are persistent and chronic. Recent studies showed that __B. burgdorferi__ can target, invade, and lyse both cultured and primary human B and T cells. Direct interactions between the spirochetes and lymphocytes also leads to adherence of B and T cell antigens on the surface of significant proportions of the bacteria . Adherent lymphocytic antigens inhibit binding of antibodies to prominent __B. burgdorferi__ proteins, and interfere with classic complement-mediated killing, suggesting a possible role for spirochete-lymphocyte interactions in immune evasion. In order to develop an experimental animal model for assessing spirochete-lymphocyte interactions, __B. burgdorferi__ and primary mouse lymphocytes were co-incubated and examined by electron microscopy. Mononuclear cells were separated from fresh mouse blood by Ficoll gradient centrifugation (ICN, Biomedicals, Aurora, Ohio).
Who reads Interactions Between Mouse Lymphocytes And Borrelia Burgdorferi , The Infectious Agent Of Lyme Disease?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Dorward, D.
- Publisher
- Oxford University Press (OUP)
- Published
- 1999
- Language
- EN
- ISBN
- 9781431927609
- Field
- Materials Science (Physical Sciences)