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Drug Delivery Systems for Localized Cancer Combination Therapy by Ryan N. Woodring; Elizabeth G. Gurysh; Eric M. Bachelder; Kristy M. Ainslie is a Materials Science article available to read on EtoBox.

What is Drug Delivery Systems for Localized Cancer Combination Therapy about?

With over 2 million cancer cases and over 600,000 cancer-associated deaths predicted in the U.S. for 2022, this lifedebilitating disease continuously impacts the lives of people across the nation every day. Therapeutic treatment options for cancer have historically involved chemotherapies to eradicate tumors with cytotoxic mechanisms which can negatively affect the efficacy versus toxicity ratio of treatment. With a need for more directed and therapeutically active options, targeted small-molecule inhibitors and immunotherapies have since emerged to mitigate treatment-associated toxicities. However, aggressive tumors can employ a wide range of defense mechanisms to evade monotherapy treatment altogether, resulting in the recurrence of therapeutically resistant tumors. Therefore, many clinical routines have included combination therapy in which anticancer agents are combined to provide a synergistic attack on tumors. Even with this approach, maximizing the efficacy of cancer treatment is contingent upon the dose of drug that reaches the site of the tumor, so often therapy is administered at the site of a tumor via localized delivery platforms. Commonly used platforms for localized d

Who reads Drug Delivery Systems for Localized Cancer Combination Therapy?

Author

Ryan N. Woodring; Elizabeth G. Gurysh; Eric M. Bachelder; Kristy M. Ainslie

Publisher

American Chemical Society (ACS)

Published

2023

Language

EN

Field

Materials Science (Physical Sciences)