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The document discusses the clonal and polyclonal nature of thyroid nodules, suggesting that both types can arise from external stimuli and may reflect different pathogenetic mechanisms. It highlights findings from various studies indicating that monoclonal lesions can develop from adjacent cells within hyperplastic lesions, leading to a clonal expansion. The coexistence of monoclonal and polyclonal nodules in thyroid pathology may indicate a progression from hyperplasia to neoplasia.

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EN