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This phase 3 trial evaluated the efficacy and tolerability of zonisamide versus controlled-release carbamazepine in adults newly diagnosed with partial epilepsy. The results indicated that zonisamide was non-inferior to carbamazepine, with 79.4% of patients in the zonisamide group achieving seizure freedom for 26 weeks compared to 83.7% in the carbamazepine group. The study suggests that zonisamide could be a viable initial monotherapy option for these patients.

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1013710137

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EN