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Efficacy of Lower Dose Pirfenidone for Idiopathic Pulmonary Fibrosis in Real Practice: a Retrospective Cohort Study by Hyeontaek Hwang; Jung-Kyu Lee; Sun Mi Choi; Yeon Joo Lee; Young-Jae Cho; Ho Il Yoon; Jae Ho Lee; Choon-Taek Lee; Young Whan Kim; Jong Sun Park is a Medicine article available to read on EtoBox.
What is Efficacy of Lower Dose Pirfenidone for Idiopathic Pulmonary Fibrosis in Real Practice: a Retrospective Cohort Study about?
## Background/aims: Pirfenidone slows the progression of idiopathic pulmonary fibrosis (ipf). we investigated its efficacy and safety in terms of dose and disease severity in real-world patients with ipf. ## Methods: This multicenter retrospective cohort study investigated 338 patients treated with pirfenidone between july 2012 and march 2018. demographics, pulmonary function, mortality, and pirfenidone-related adverse events were also investigated. efficacy was analyzed according to pirfenidone dose and disease severity using linear mixed-effects models to assess the annual decline rate of forced vital capacity (fvc) and diffusing capacity of the lungs for carbon monoxide (dlco). ## Results: The mean %fvcpredicted and %dlcopredicted values were 72.6% ± 13.1% and 61.4% ± 17.9%, respectively. the mean duration of pirfenidone treatment was 16.1 ± 9.0 months. in the standard dose (1,800 mg/day) group, the mean %fvcpredicted was -6.56% (95% confidence interval [ci], -9.26 to -3.87) per year before, but -4.43% (95% ci, -5.87 to -3.00) per year after treatment with pirfenidone. in the non-standard lower dose group, the mean %fvcpredicted was -4.96% (95% ci, -6.82 to -3.09) per year befor
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- Author
- Hyeontaek Hwang; Jung-Kyu Lee; Sun Mi Choi; Yeon Joo Lee; Young-Jae Cho; Ho Il Yoon; Jae Ho Lee; Choon-Taek Lee; Young Whan Kim; Jong Sun Park
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)