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Teratogenic assessment of four solvents using the frog embryo teratogenesis assay— xenopus (FETAX) by Todd H. Dresser; Edna R. Rivera; Florence J. Hoffmann; Robert A. Finch is a Environmental Science article available to read on EtoBox.

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The Frog Embryo Teratogenesis Assay-Xenopus (FETAX) was used to assess the teratogenic potential of four solvents. Embryos of the South African clawed frog, Xenopus laevis, were exposed for 96 h to ethanol, dimethyl sulfoxide (DMSO), formamide or glycerol formal. Exposure groups were maintained using a static renewal system in which the exposure media were changed at 24-h intervals. Survival was monitored at 24h intervals. Length, as an indicator of growth effects, and developmental malformations were determined at the end o f the assay (96 h). Using this information, the 96-h L C ~~, the 96-h E C ~~ (Malformation), and the no observable effect levels (NOELs) for mortality, malformation and length were determined for each solvent. The teratogenic index [TI = 96-h LcJ%-h E C ~~ (Malformation)] also was calculated for each of the solvents. DMSO apeared to be the least toxic or teratogenic solvent examined, with a pooled L C ~ of 1.92%, a pooled ## E C ~~ (Malformation) of 1.57% and TI values of 1.20 and 1.24 in replicate trials. Formamide appeared to be the most toxic solvent, with a pooled LC-of 1.04%. Data trends suggested that ethanol was the most teratogenic solvent tested, with

Who reads Teratogenic assessment of four solvents using the frog embryo teratogenesis assay— xenopus (FETAX)?

Author

Todd H. Dresser; Edna R. Rivera; Florence J. Hoffmann; Robert A. Finch

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)

Published

1992

Language

EN

Field

Environmental Science (Physical Sciences)