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Efficacy and Tolerability of Limited Field Radiotherapy with Concurrent Capecitabine in Locally Advanced Pancreatic Cancer by A.S.N. Jackson; P. Jain; G.R. Watkins; G.A. Whitfield; M.M. Green; J. Valle; M.B. Taylor; C. Dickinson; P.M. Price; A. Saleem is a Medicine article available to read on EtoBox.
What is Efficacy and Tolerability of Limited Field Radiotherapy with Concurrent Capecitabine in Locally Advanced Pancreatic Cancer about?
Aims: Patients with locally advanced pancreatic cancer (LAPC) are most commonly managed with chemotherapy or concurrent chemoradiotherapy (CRT), which may or may not include non-involved regional lymph nodes in the clinical target volume. We present our results of CRT for LAPC using capecitabine and delivering radiotherapy to a limited radiation field that excluded non-involved regional lymph nodes from the clinical target volume. Materials and methods: Thirty patients were studied. Patients received 50.4 Gy external beam radiotherapy in 28 fractions, delivered to a planning target volume expanded from the primary tumour and involved nodes only. Capecitabine (500e600 mg/m 2 ) was given twice daily continuously during radiotherapy. Toxicity and efficacy data were prospectively collected. Results: Nausea, vomiting and tumour pain were the most common grade 2 toxicities. One patient developed grade 3 nausea. The median time to progression was 8.8 months, with 20% remaining progression free at 1 year. The median overall survival was 9.7 months with a 1 year survival of 30%. Of 21 patients with imaged progression, 13 (62%) progressed systemically, three (14%) had local progression, two
Who reads Efficacy and Tolerability of Limited Field Radiotherapy with Concurrent Capecitabine in Locally Advanced Pancreatic Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- A.S.N. Jackson; P. Jain; G.R. Watkins; G.A. Whitfield; M.M. Green; J. Valle; M.B. Taylor; C. Dickinson; P.M. Price; A. Saleem
- Publisher
- Elsevier Science; Springer; Elsevier ; Springer-Verlag; W. B. Saunders Co., Ltd.; Springer Verlag; Elsevier BV; Springer Science and Business Media LLC (ISSN 1433-2981)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)