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Can I read Coronary Risks Associated with Diclofenac and Other NSAIDs: An Update on EtoBox?
Coronary Risks Associated with Diclofenac and Other NSAIDs: An Update by Nicholas Moore is a Medicine article available to read on EtoBox.
What is Coronary Risks Associated with Diclofenac and Other NSAIDs: An Update about?
The risk of coronary events with non-steroidal anti-inflammatory drugs has been the subject of much debate since the original trial of rofecoxib raised the issue. Since then, over almost 20 years, such risks have been shown in clinical trials of long-term high-dose users, and in observational studies comparing users with non-users. The roles of cyclooxygenase (COX)-2/COX-1 selectivity and COX-2 inhibitory potency have been proposed to explain this increased risk of myocardial infarction (MI). Among NSAIDs, diclofenac appeared to be associated with a relatively higher risk of MI, similar to that of rofecoxib, compatible with the drug's high COX-2 inhibitory potency. Recent studies have resulted in further information being available. A study in the Danish healthcare system using active comparators found a slightly increased risk of MI in healthy persons. However, risk decreased with increasing baseline cardiovascular risk, to the point that in patients at high cardiovascular risk, there was no additional risk associated with diclofenac compared with paracetamol or other NSAIDs. The other major study, from the SOS project, studied several million persons in four countries in Europe,
Who reads Coronary Risks Associated with Diclofenac and Other NSAIDs: An Update?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Nicholas Moore
- Publisher
- Springer Science and Business Media LLC
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)