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Tretinoin 0.1% and Benzoyl Peroxide 3% Cream for the Treatment of Facial Acne Vulgaris by Christina Kontzias; Mallory Zaino; Steven R. Feldman is a Medicine article available to read on EtoBox.

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## Objective: To assess the efficacy, safety, and clinical application of tretinoin 0.1%-benzoyl peroxide 3% cream for the topical treatment of acne vulgaris. ## Data Sources: A systematic review of the literature was performed using the terms Twyneo OR tretinoin and benzoyl peroxide OR S6G5T-3 in MEDLINE (PubMed) and EMBASE. ClinicalTrials.gov was searched to obtain completed clinical trial results not published elsewhere. ## Study Selection and Data Extraction: All human studies published in English prior to November 2022 related to pharmacology, clinical trials, safety, and efficacy were evaluated for inclusion. ## Data Synthesis: In two 12-week, phase 3, randomized, vehicle-controlled clinical trials, tretinoin 0.1%-benzoyl peroxide 3% cream significantly reduced inflammatory and noninflammatory facial acne lesions and significantly improved Investigator Global Assessment (IGA) rating to clear or almost clear. The cream has a suitable safety profile, with application site pain and dryness as the most common adverse events. ## Relevance to Patient Care and Clinical Practice in Comparison to Existing Agents: Tretinoin-BPO had similar IGA success compared to other topical retinoid

Who reads Tretinoin 0.1% and Benzoyl Peroxide 3% Cream for the Treatment of Facial Acne Vulgaris?

Author

Christina Kontzias; Mallory Zaino; Steven R. Feldman

Publisher

SAGE Publications

Published

2023

Language

EN

Field

Medicine (Health Sciences)