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Pharmacologic Inhibition of Particulate-induced Bone Resorption by Stephen M. Horowitz; Sheila A. Algan; Marie A. Purdon is a Medicine article available to read on EtoBox.

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In this study, a rat calvaria/macrophage co-culture model was used to study the effects of various agents upon bone resorption induced by macrophage exposure to bone cement particles. The experimental group consisted of calvaria bone disks set in tissue culture medium on stainless-steel platforms into wells with macrophages adherent to the bottom which are exposed to the particles. Tumor necrosis factor a (TNF-a), prostaglandin E, (PGEp), and calcium 45 (Ca45) were released in significant amounts in this system. Interleukin la (IL-la) was not detected. Indomethacin inhibited the production of PGE2, but did not affect TNF release or inhibit the release of Ca4'. Anti-TNF antibody neutralized the presence of TNF to undetectable levels, but did not affect PGEz release or inhibit Ca45 release. The addition of calcitonin did not inhibit Ca45 release by calvaria. In contrast, the addition of disodium pamidronate, a member of the bisphosphonate family, was effective in inhibiting the release of Ca4' even after 96 h of incubation. In prior studies, incubation of calvaria in conditioned medium from macrophages exposed to cement particles led to resorption through a mechanism which is depende

Who reads Pharmacologic Inhibition of Particulate-induced Bone Resorption?

Author

Stephen M. Horowitz; Sheila A. Algan; Marie A. Purdon

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

1996

Language

EN

Field

Medicine (Health Sciences)