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Can I read SARS-CoV-2 main protease (3CLpro) interaction with acyclovir antiviral drug/methyl-β-cyclodextrin complex: Physiochemical characterization and molecular docking on EtoBox?
SARS-CoV-2 main protease (3CLpro) interaction with acyclovir antiviral drug/methyl-β-cyclodextrin complex: Physiochemical characterization and molecular docking by Sonaimuthu Mohandoss; Ramaraj Sukanya; Sivarasan Ganesan; Fatemah H. Alkallas; Amira Ben Gouider Trabelsi; Fedor V. Kusmartsev; Kuppu Sakthi Velu; Thambusamy Stalin; Huang-Mu Lo; Yong Rok Lee is a Chemical Engineering article available to read on EtoBox.
What is SARS-CoV-2 main protease (3CLpro) interaction with acyclovir antiviral drug/methyl-β-cyclodextrin complex: Physiochemical characterization and molecular docking about?
During the current outbreak of the novel coronavirus disease 2019 (COVID-19), researchers have examined several antiviral drugs with the potential to inhibit the proliferation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The antiviral drug acyclovir (AVR), which is used to treat COVID-19, in complex with methyl-β-cyclodextrin (Mβ-CD) was examined in the solution and solid phases. UV–visible and fluorescence spectroscopic analyses confirmed that the guest (AVR) was included inside the host (Mβ-CD) cavity. A solid inclusion complex of AVR was prepared by co-precipitation, physical mixing, kneading, and bath sonication methods at a 1:1 ratio of Mβ-CD:AVR. The prepared Mβ-CD:AVR inclusion complex was characterized using Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analysis. Phase solubility studies indicated the Mβ-CD:AVR inclusion complex exhibited a higher stability constant and linear enhancement in AVR solubility with increasing Mβ-CD concentrations. In silico analysis of the Mβ-CD/AVR inclusion complex confirme
Who reads SARS-CoV-2 main protease (3CLpro) interaction with acyclovir antiviral drug/methyl-β-cyclodextrin complex: Physiochemical characterization and molecular docking?
It is typically read by researchers, students, and practitioners in Chemical Engineering.
- Author
- Sonaimuthu Mohandoss; Ramaraj Sukanya; Sivarasan Ganesan; Fatemah H. Alkallas; Amira Ben Gouider Trabelsi; Fedor V. Kusmartsev; Kuppu Sakthi Velu; Thambusamy Stalin; Huang-Mu Lo; Yong Rok Lee
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Chemical Engineering (Physical Sciences)