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Can I read Lactobacillus rhamnosus MN‐431 Metabolic Tryptophan Alleviates Complementary Food‐Induced Diarrhea through PXR–NF‐κB Pathway and AHR–Th17 Cell Response Pathways on EtoBox?
Lactobacillus rhamnosus MN‐431 Metabolic Tryptophan Alleviates Complementary Food‐Induced Diarrhea through PXR–NF‐κB Pathway and AHR–Th17 Cell Response Pathways by Haiyue Niu; Xiaohong Zhou; Ping Liu; Yifan Wu; Linzheng Lyu; Tongjie Liu; Zhe Zhang; Jiliang Zhang; Shiwei Chen; Pimin Gong; Xue Han; Lanwei Zhang is a Medicine article available to read on EtoBox.
What is Lactobacillus rhamnosus MN‐431 Metabolic Tryptophan Alleviates Complementary Food‐Induced Diarrhea through PXR–NF‐κB Pathway and AHR–Th17 Cell Response Pathways about?
Scope: Lactobacillus rhamnosus MN-431 tryptophan broth culture (MN-431TBC) could prevent CFID. However, it was not clear whether this effect was related to indole derivatives. Methods and results: In this study, the anti-CFID effects of different components in MN-431 TBC including MN-431 cells, unfermented tryptophan broth, and supernatant of MN-431 TBC (MN-431 TBS) were investigated. Only MN-431 TBS could significantly prevent CFID, indicating that indole derivatives produced by MN-431 could exert antidiarrheal effects. Intestinal morphological analysis revealed that MN-431 TBS could increase the number of goblet cells, height of ileal villi, and length of rectal glands while also increasing the expression of ZO-1 in colon. Furthermore, HPLC analysis revealed the indole derivatives in MN-431 TBS were IAld and skatole. Cell experiments demonstrated that MN-431 TBS promoted the transcription of AHR and PXR, comparable to the synergistic effect of IAld and skatole. MN-431 TBS could activate AHR and reduce the concentrations of Th17 cell-inflammatory factors IL-17A and IL-21 in intestine and IL-17F, IL-21, and IL-22 in serum. MN-431 TBS could also activate PXR and reduce the concentra
Who reads Lactobacillus rhamnosus MN‐431 Metabolic Tryptophan Alleviates Complementary Food‐Induced Diarrhea through PXR–NF‐κB Pathway and AHR–Th17 Cell Response Pathways?
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- Author
- Haiyue Niu; Xiaohong Zhou; Ping Liu; Yifan Wu; Linzheng Lyu; Tongjie Liu; Zhe Zhang; Jiliang Zhang; Shiwei Chen; Pimin Gong; Xue Han; Lanwei Zhang
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)