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Pharmacokinetics of Oral Diclofenac and Acetaminophen in Children After Surgery by Janne Rømsing ; Doris Østergaard ; Thomas Senderovitz ; Dominika Drozdziewicz ; Jesper Sonne ; Grete Ravn is a Medicine article available to read on EtoBox.

What is Pharmacokinetics of Oral Diclofenac and Acetaminophen in Children After Surgery about?

__Background__: Our aim was to study the pharmacokinetics and pain scores following administration of single oral doses of either diclofenac or high‐dose acetaminophen (paracetamol). __Methods__: In the morning, the day after tonsillectomy, children 5–15 years of age were randomized in a double‐blind manner to receive either diclofenac 1–2 mg·kg^−1^ (__n__=11) or acetaminophen 22.5 mg·kg^−1^ (__n__=10). Postoperative pain was assessed by self‐report and blood samples were drawn every 30 min for 4 h after medication. __Results__: Large interindividual differences in maximum plasma diclofenac concentrations (__C__~max~) were found. Mean __C__~max~ was 2.4±1.3 μg·ml^−1^ and mean __t__~max~ was 2±0.5 h. No significant reduction in pain score with diclofenac was seen at any of the assessments during the study period. Eight of 10 children achieved __C__~max~ of acetaminophen within the 10–20 μg·ml^−1^ antipyretic range. Mean __t__~abs~ was 0.7±0.3 h and mean __C__~max~ and __t__~max~ were 12.7±3.8 μg ml^−1^ and 1.4±0.5 h, respectively. No significant reduction in pain score with acetaminophen was seen at any of the assessments during the study period. __Conclusions__: The achieved concen

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Author

Janne Rømsing ; Doris Østergaard ; Thomas Senderovitz ; Dominika Drozdziewicz ; Jesper Sonne ; Grete Ravn

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1155-5645)

Published

2001

Language

EN

Field

Medicine (Health Sciences)