About this Medicine article
Biosynthesis of anti-leishmanial natural products in callus cultures of Artemisia scoparia by M. Khan is a Medicine article available to read on EtoBox.
Background: Efavirenz, widely used as first line antiretroviral therapy (ART), is frequently associated with mild transient neuropsychiatric symptoms, usually occurring early in therapy. More severe neurotoxicity has been reported, but the clinical phenotype and risk factors are poorly defined. Methods and materials: We identified adult patients with an efavirenz concentration >4 mg/L (target 1-4 mg/L) at four hospitals in Cape Town, South Africa. Data were extracted from medical records, including clinical symptoms and signs and laboratory abnormalities at the time of efavirenz quantification; severe neurotoxicity was defined as Division of AIDS score > 3. We performed logistic regression to identify associations with neuropsychiatric symptoms and severe neurotoxicity. Results: Data were included from 82 patients: 62 had neuropsychiatric symptoms, 19 had hepatitis, and 1 had no apparent indication for efavirenz quantification. Median age was 38 years (interquartile range (IQR) 29-45), median weight 53 kg (IQR 44-63), 29 (34%) were male, and 49 (63%) patients had concomitant isoniazid exposure. Median efavirenz concentration was 12.1 mg/L (IQR 6.6-20.0). Neuropsychiatric manifestat
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- Author
- M. Khan
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)