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Microfluidic Approaches for Systems and Synthetic Biology by Nicolas Szita; Karen Polizzi; Nicolas Jaccard; Frank Baganz is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Microfluidic Approaches for Systems and Synthetic Biology about?

Microfluidic systems miniaturise biological experimentation leading to reduced sample volume, analysis time and cost. Recent innovations have allowed the application of -omics approaches on the microfluidic scale. It is now possible to perform 1.5 million PCR reactions simultaneously, obtain transcriptomic data from as little as 150 cells (as few as 2 transcripts per gene of interest) and perform mass-spectrometric analyses online. For synthetic biology, unit operations have been developed that allow de novo construction of synthetic systems from oligonucleotide synthesis through to high-throughput, high efficiency electroporation of single cells or encapsulation into abiotic chassis enabling the processing of thousands of synthetic organisms per hour. Future directions include a push towards integrating more processes into a single device and replacing off-chip analyses where possible.

Who reads Microfluidic Approaches for Systems and Synthetic Biology?

Author

Nicolas Szita; Karen Polizzi; Nicolas Jaccard; Frank Baganz

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0958-1669)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)