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This article investigates the genetic basis of schizophrenia, highlighting the association of the disorder with variations in the complement component 4 (C4) genes located in the major histocompatibility complex (MHC) locus. The study reveals that different alleles of C4 lead to varying levels of C4A and C4B expression in the brain, with higher C4A expression correlating with increased schizophrenia risk. These findings suggest that excessive complement activity may contribute to the synaptic deficits obser

Author

liucatlin

Language

EN