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Zeaxanthin augments CD8+ effector T cell functionand immunotherapy efficacy by Freya Q. Zhang & Jiacheng Li & Rukang Zhang & Jiayi Tu & Zhicheng Xie & Takemasa Tsuji & Hardik Shah & Matthew O. Ross & Ruitu Lyu & Junko Matsuzaki & Anna Tabor & Kelly Xue & Fatima Choudhry & Chunzhao Yin & Hamed R. Youshanlouei & Syed Shah & Michael... is a nonfiction available to read on EtoBox.

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Cell Reports Medicine, Corrected proof, 102324. doi:10.1016/j.xcrm.2025.102324SUMMARYThe detailed mechanisms underlying the regulatory significance of dietary components in modulating antitumor immunity remain largely unknown. Here, we apply a co-culture-based screening approach using ablood nutrient compound library and identify zeaxanthin (ZEA), a dietary carotenoid pigment found inmany fruits and vegetables and known for its role in eye health, as an immunomodulator that enhancesthe cytotoxicity of CD8+ T cells against tumor cells. Oral supplementation with ZEA, but not its structural isomer lutein (LUT), enhances anti-tumor immunity in vivo. Integrated multi-omics mechanistic studies revealthat ZEA promotes T cell receptor (TCR) stimulation on the CD8+ T cell surface, leading to improved intracellular TCR signaling for effector T cell function. Hence, ZEA treatment augments the efficacy of anti-PD1 immune checkpoint inhibitor in vivo and the cytotoxicity of human TCR gene-engineered CD8+ T cells in vitro.Our findings uncover a previously unknown immunoregulatory function of ZEA, which has translationalpotential as a dietary element in bolstering immunotherapy.

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Author

Freya Q. Zhang & Jiacheng Li & Rukang Zhang & Jiayi Tu & Zhicheng Xie & Takemasa Tsuji & Hardik Shah & Matthew O. Ross & Ruitu Lyu & Junko Matsuzaki & Anna Tabor & Kelly Xue & Fatima Choudhry & Chunzhao Yin & Hamed R. Youshanlouei & Syed Shah & Michael...

Publisher

The Author(s)

Published

2025

Language

EN

Category

nonfiction

Subjects

Medical, Immunology, Medicine