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CETP Taq1B polymorphism and its association with cardiovascular risk factors in an Iranian population under angiography, A Cross-Sectional Study by Azam Ahmadi Vasmehjani; SeyedMostafa SeyedHosseini; SayyedSaeid Khayyatzadeh; Farzan Madadizadeh; Mahta Mazaheri-Naeini; Mahdie Yavari; Zahra Darabi; Sara Beigrezaei; Marzieh Taftian; Vahid Arabi; Maryam Motallaei; Amin Salehi-Abargouei; Azadeh Najarzadeh is a scholarly article available to read on EtoBox.

What is CETP Taq1B polymorphism and its association with cardiovascular risk factors in an Iranian population under angiography, A Cross-Sectional Study about?

Abstract Background: Several studies have assessed the association of the cholesterol ester transfer protein (CETP) (rs708272) TaqIB gene polymorphism with risk factors of CVDs; however, their results are inconsistent. The current study investigated the relationship between CVD risk factors and the Taq1B variant in a population from Iran that was undergoing coronary angiography. Methods: This cross-sectional study was conducted on 476 subjects aged (30-76) years of both sexes. Genotypes for Taq1B polymorphism were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using extracted DNA from whole blood. Cardio-metabolic markers were measured by standard protocols. To determine the association between CVDs risk factors and the rs708272 variant, binary logistic regression was used in crude and adjusted models. Results: Genotype frequencies of the Taq1B polymorphism were 10.7% for B1B1, 72.3% for B1B2, and 17% for B2B2. No significant association was observed between abnormal levels of CVDs risk factors and different genotypes of the Taq1B variant, Gensini score (p= 0.64), Syntax score (p = 0.79), systolic blood pressure (p = 0.55), diastolic blo

Author

Azam Ahmadi Vasmehjani; SeyedMostafa SeyedHosseini; SayyedSaeid Khayyatzadeh; Farzan Madadizadeh; Mahta Mazaheri-Naeini; Mahdie Yavari; Zahra Darabi; Sara Beigrezaei; Marzieh Taftian; Vahid Arabi; Maryam Motallaei; Amin Salehi-Abargouei; Azadeh Najarzadeh

Publisher

Research Square Platform LLC

Published

2023

Language

EN