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Towards the synthesis of HIV-protease inhibitors. Synthesis optically pure 3-carboxyl-decahydroisoquinolines. by Ioannis N. Houpis; Audrey Molina; Robert A. Reamer; Joseph E. Lynch; R.P. Volante; Paul J. Reider is a Chemistry article available to read on EtoBox.

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The synthesis of optically pure decahydroisoquinoline 1, a component of HIV-protease inhibitors, was accomplished in 30-33% overall yield from the madily available optically pure monoacid 4. Decahydroisoquin0line-3-carboxylic acid derivatives, A, have received increasing attention in recent years due to their usefulmzss in the preparation of thempeutic agents1 especially N-methyl-D-aspardc acid antagonisk2 Recently, the N-tert-butyldecahydroisoquinoline-3carbo 1 has been incorporated in the

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Author

Ioannis N. Houpis; Audrey Molina; Robert A. Reamer; Joseph E. Lynch; R.P. Volante; Paul J. Reider

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)

Published

1993

Language

EN

Field

Chemistry (Physical Sciences)