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Can I read Synthesis of tritium-labeled DL-γ-carboxyglutamic acid and its cyclic form 5-oxo-2,4-pyrrolidine dicarboxylic acid on EtoBox?
Synthesis of tritium-labeled DL-γ-carboxyglutamic acid and its cyclic form 5-oxo-2,4-pyrrolidine dicarboxylic acid by Yoshinori Ishikawa; Roy E. Wuthier is a Medicine article available to read on EtoBox.
What is Synthesis of tritium-labeled DL-γ-carboxyglutamic acid and its cyclic form 5-oxo-2,4-pyrrolidine dicarboxylic acid about?
By condensing diethyl ethoxymethylenemalonate with diethyl acetamidomalonate, 5-hydroxy-2,4-dicarbethoxypyrrole was prepared. Hydrogenation over Pt-C to 5-oxo-2,4-dicarbethoxypyrrolidine, followed by alkaline hydrolysis gave y-carboxyglutamate. Mild alkaline hydrolysis yielded 5-oxo-2,4-pyrrolidine dicarboxylic acid which was isolated as the cyclohexylamine salt. These procedures were applied to prepare tritium-labeled y-carboxyglutamic acid ( 4 . 9 Ci/mmol) and its cyclic form (6.1 ci/mmol).
Who reads Synthesis of tritium-labeled DL-γ-carboxyglutamic acid and its cyclic form 5-oxo-2,4-pyrrolidine dicarboxylic acid?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yoshinori Ishikawa; Roy E. Wuthier
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)
- Published
- 1984
- Language
- EN
- Field
- Medicine (Life Sciences)