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Can I read Increased Plasma Homocysteine Levels in Patients with Multiple Sclerosis and Depression on EtoBox?
Increased Plasma Homocysteine Levels in Patients with Multiple Sclerosis and Depression by Nikolaos Triantafyllou; Maria-Eleftheria Evangelopoulos; Vasilios K Kimiskidis; Evangelia Kararizou; Fotini Boufidou; Konstantinos N Fountoulakis; Melina Siamouli; Chrysoula Nikolaou; Constantinos Sfagos; Nikolaos Vlaikidis; Dimitrios Vassilopoulos is a Medicine article available to read on EtoBox.
What is Increased Plasma Homocysteine Levels in Patients with Multiple Sclerosis and Depression about?
## Background The aim of the study was to assess the plasma levels of homocysteine in patients with multiple sclerosis (MS) and to investigate whether an association with depression exists. ## Methods Plasma homocysteine (Hcy), vitamin B12 and plasma folate were measured in 65 moderately disabled patients with relapsing/remitting MS (RR-MS) and 60 healthy controls. All subjects were assessed with the Beck Depression Inventory (BDI). ## Results Hcy levels were significantly increased in MS patients compared to controls (13.5 ± 4.7 μmol/l vs 8.5 ± 3.1, p < 0.001). A significant correlation was found between Hcy levels and BDI scores (Pearson r = 0.3025, p < 0.05). Plasma Hcy was not related to Extended Disability Status Scale (EDSS) score, age, disease duration or vitamin B12 and folate. ## Conclusion Moderately disabled MS patients with elevated Hcy levels are particularly prone to develop depressive symptomatology. Further study is warranted in order to elucidate the prognostic and therapeutic implications of this novel finding.
Who reads Increased Plasma Homocysteine Levels in Patients with Multiple Sclerosis and Depression?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Nikolaos Triantafyllou; Maria-Eleftheria Evangelopoulos; Vasilios K Kimiskidis; Evangelia Kararizou; Fotini Boufidou; Konstantinos N Fountoulakis; Melina Siamouli; Chrysoula Nikolaou; Constantinos Sfagos; Nikolaos Vlaikidis; Dimitrios Vassilopoulos
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2005-; Springer Science and Business Media LLC (ISSN 1744-859X)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)