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Can I read Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment on EtoBox?
Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment by Anna Delprato; Emily Xiao; Devika Manoj is a Neuroscience article available to read on EtoBox.
What is Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment about?
Genetic variants of __DCX__, __COMT__ and __FMR1__ have been linked to neurodevelopmental disorders related to intellectual disability and social behavior. In this systematic review we examine the roles of the __DCX__, __COMT__ and __FMR1__ genes in the context of hippocampal neurogenesis with respect to these disorders with the aim of identifying important hubs and signaling pathways that may bridge these conditions. Taken together our findings indicate that factors connecting __DCX__, __COMT,__ and __FMR1__ in intellectual disability and social behavior may converge at Wnt signaling, neuron migration, and axon and dendrite morphogenesis. Data derived from genomic research has identified a multitude of genes that are linked to brain disorders and developmental differences. Information about where and how these genes function and cooperate is lagging behind. The approach used here may help to shed light on the biological underpinnings in which key genes interface and may prove useful for the testing of specific hypotheses. ## Supplementary Information The online version contains supplementary material available at 10.1186/s12993-022-00191-7.
Who reads Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Anna Delprato; Emily Xiao; Devika Manoj
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Neuroscience (Life Sciences)