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Validation of AML-score in Older Adults Receiving CPX-351 Intensive Induction Chemotherapy for Treatment of Secondary Acute Myeloid Leukemia by Abigail M. Schmucker; Benjamin E. Leiby; Lindsay Wilde is a Medicine article available to read on EtoBox.

What is Validation of AML-score in Older Adults Receiving CPX-351 Intensive Induction Chemotherapy for Treatment of Secondary Acute Myeloid Leukemia about?

The AML-Score is a web-based tool that was designed to predict the risk of complete remission and early mortality in older patients with acute myeloid leukemia being treated with traditional induction chemotherapy. This retrospective study of 40 patients assesses the validity of the AML-Score in a cohort of older patients with secondary AML who received induction chemotherapy with the newer agent, CPX-351. Results of the study show that the AML-Score trends in the correct direction for predicting CR and EM in this patient population and may facilitate oncologist decision making when considering treatment with CPX-351. Introduction/Background: The AML-Score has been validated in patients receiving traditional induction chemotherapies but not CPX-351. We conducted a retrospective analysis to evaluate, among patients with secondary acute myeloid leukemia who received intensive induction with CPX-351, if the AML-Score associates with (1) complete remission (CR) and (2) early mortality (EM) within 60 days of induction. Materials and Methods: We abstracted demographic and clinical data from consecutive patients receiving CPX-351 at Sidney Kimmel Cancer Center at Thomas Jefferson Universi

Who reads Validation of AML-score in Older Adults Receiving CPX-351 Intensive Induction Chemotherapy for Treatment of Secondary Acute Myeloid Leukemia?

Author

Abigail M. Schmucker; Benjamin E. Leiby; Lindsay Wilde

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)