Can I read Beneficial effects of denosumab on muscle performance in patients with low BMD: a retrospective, propensity score-matched study on EtoBox?

Beneficial effects of denosumab on muscle performance in patients with low BMD: a retrospective, propensity score-matched study by Tobias Rupp; Emil von Vopelius; André Strahl; Ralf Oheim; Florian Barvencik; Michael Amling; Tim Rolvien is a Medicine article available to read on EtoBox.

What is Beneficial effects of denosumab on muscle performance in patients with low BMD: a retrospective, propensity score-matched study about?

## Summary This study examined the effects of denosumab compared to bisphosphonates and vitamin D alone on muscle performance in patients with low BMD. While grip force improved in both the denosumab and bisphosphonate group, a superior increase in chair rising test force was observed in the denosumab group. ## Introduction The aim of this study was to investigate the effect of the anti-resorptive agent denosumab (Dmab) on upper and lower limb muscle performance compared to bisphosphonate (BP) treatment and vitamin D supplementation alone (i.e., basic therapy) in patients with low BMD. ## Methods This retrospective, propensity score-matched (sex, age, BMI, follow-up time) cohort study included 150 osteopenic or osteoporotic patients receiving basic (__n__ = 60), BP (__n__ = 30) or Dmab (__n__ = 60) therapy. All patients underwent a musculoskeletal assessment at baseline and follow-up, including DXA, laboratory bone metabolism parameters, grip force, and chair rising test mechanography. Mean annual percentage changes were calculated and compared between study groups. ## Results After a mean follow-up period of 17.6 ± 9.0 months, a significantly higher increase in grip force in both

Who reads Beneficial effects of denosumab on muscle performance in patients with low BMD: a retrospective, propensity score-matched study?

Author

Tobias Rupp; Emil von Vopelius; André Strahl; Ralf Oheim; Florian Barvencik; Michael Amling; Tim Rolvien

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)