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Effects of immunosuppression-associated gga-miR-146a-5p on immune regulation in chicken macrophages by targeting the IRKA2 gene by Zhaoyan Zhu; Aru Su; Bingxin Wang; Yange Yu; Xiaoran Wang; Xiaoxiao Li; Yujie Guo; Yancheng Zhou; Yadong Tian; Guirong Sun; Xiangtao Kang; Fengbin Yan is a Immunology and Microbiology article available to read on EtoBox.
What is Effects of immunosuppression-associated gga-miR-146a-5p on immune regulation in chicken macrophages by targeting the IRKA2 gene about?
Stress-induced immunosuppression (SIIS) is one of the common problems in intensive poultry production, which brings enormous economic losses to the poultry industry. Accumulating evidence has shown that microRNAs (miRNAs) were important regulators of gene expression in the immune system. However, the miRNA-mediated molecular mechanisms underlying SIIS in chickens are still poorly understood. This study aimed to investigate the biological functions and regulatory mechanism of miRNAs in chicken SIIS. A stress-induced immunosuppression model was successfully established via daily injection of dexamethasone and analyzed miRNA expression in spleen. Seventy-four differentially expressed miRNAs (DEMs) was identified, and 229 target genes of the DEMs were predicted. Functional enrichment analysis the target genes revealed pathways related to immunity, such as MAPK signaling pathway and FoxO signaling pathway. The candidate miRNA, gga-miR-146a-5p, was found to be significantly downregulated in the Dex-induced chicken spleen, and we found that Dex stimulation significantly inhibited the expression of gga-miR-146a-5p in Chicken macrophages (HD11). Flow cytometry, 5-ethynyl-2′-deoxyuridine (Ed
Who reads Effects of immunosuppression-associated gga-miR-146a-5p on immune regulation in chicken macrophages by targeting the IRKA2 gene?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Zhaoyan Zhu; Aru Su; Bingxin Wang; Yange Yu; Xiaoran Wang; Xiaoxiao Li; Yujie Guo; Yancheng Zhou; Yadong Tian; Guirong Sun; Xiangtao Kang; Fengbin Yan
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)