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Can I read In vivo mutagenesis in the cynomolgus monkey: Time course of HPRT mutant frequency at long time points following ethylnitrosourea exposure on EtoBox?
In vivo mutagenesis in the cynomolgus monkey: Time course of HPRT mutant frequency at long time points following ethylnitrosourea exposure by David M. Zimmer; Charles S. Aaron is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is In vivo mutagenesis in the cynomolgus monkey: Time course of HPRT mutant frequency at long time points following ethylnitrosourea exposure about?
We have monitored mutant frequency at the HPRT for 6 years, and a second identical treatment was locus in peripheral blood lymphocytes of cynomol-given about 830 days after the first. Mutant fregus monkeys using a clonal assay in which mutants quency again peaked in these two animals 70 days are selected by resistance to 6-thioguanine. Among after the second dose and decreased following untreated animals, the mean spontaneous mutant peak values, declining to a plateau that was higher frequency was 2.9 { 2.9 1 10 06 (standard devia-than the predose mutant frequency in both animals. tion, based on 131 determinations in 33 animals), This pattern was repeated following the second in good agreement with HPRT mutant frequencies in ethylnitrosourea treatment. Fractionating the dose other species. In four animals treated with a single of ethylnitrosourea into five equal daily injections intraperitoneal dose of 77 mg/kg ethylnitrosourea, had no effect on mutant frequency in two animals mutant frequency increased with time, peaking 70 when compared to a single dose. Environ. Mol. to 100 days after treatment. Mutant frequency in Mutagen. 29:117 -123, 1997 two of the four animals was monitored
Who reads In vivo mutagenesis in the cynomolgus monkey: Time course of HPRT mutant frequency at long time points following ethylnitrosourea exposure?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- David M. Zimmer; Charles S. Aaron
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0893-6692)
- Published
- 1997
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)