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Impact of Probiotics on the Salivary Microbiota and Salivary Levels of Inflammation-Related Proteins during Short-Term Sugar Stress: A Randomized Controlled Trial by Christine Lundtorp-Olsen; Christian Enevold; Claus Antonio Juel Jensen; Steen Nymann Stofberg; Svante Twetman; Daniel Belstrøm is a Medicine article available to read on EtoBox.
What is Impact of Probiotics on the Salivary Microbiota and Salivary Levels of Inflammation-Related Proteins during Short-Term Sugar Stress: A Randomized Controlled Trial about?
Background: The purpose of the present investigation was to characterize the effect of probiotics on the composition of the salivary microbiota and salivary levels of inflammation-related proteins during short-term sugar stress. We tested the hypotheses that consumption of probiotics may partly counteract the detrimental influence of sugar stress on oral homeostasis. Methods: The present study was a five-week, blinded, randomized controlled trial with four study arms—A: sucrose and probiotic (__n__ = 20); B: sucrose and placebo (__n__ = 20); C: xylitol and probiotic (__n__ = 20); D: xylitol and placebo (__n__ = 20). Saliva samples were collected at baseline and after two and five weeks. The salivary microbiota was characterized by means of 16S rDNA sequencing, and sequences were referenced against the Human Oral Microbiome Database (HOMD). Neutrophil gelatinase-associated lipocalin (NGAL) and transferrin levels were quantified using immunoassays. Results: Sugar stress induced a significant increase in the relative abundance of the genus __Streptococcus__ from 29.8% at baseline to 42.9% after two weeks. Changes were transient and were completely reversed three weeks after discontinu
Who reads Impact of Probiotics on the Salivary Microbiota and Salivary Levels of Inflammation-Related Proteins during Short-Term Sugar Stress: A Randomized Controlled Trial?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Christine Lundtorp-Olsen; Christian Enevold; Claus Antonio Juel Jensen; Steen Nymann Stofberg; Svante Twetman; Daniel Belstrøm
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Medicine (Life Sciences)