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Improving the Accuracy of Pdot-Based Continuous Glucose Monitoring by Using External Ratiometric Calibration by Kai Sun; Siyang Liu; Jing Liu; Zhaoyang Ding; Yifei Jiang; Jicheng Zhang; Haobin Chen; Jiangbo Yu; Changfeng Wu; Daniel T. Chiu is a Chemistry article available to read on EtoBox.
What is Improving the Accuracy of Pdot-Based Continuous Glucose Monitoring by Using External Ratiometric Calibration about?
Continuous glucose monitoring (CGM) allows type I and II diabetes patients to track changes in their glucose levels, allowing detection of impending hypoglycemia or hyperglycemia. Polymer dots (Pdots) are candidates for use in implanted CGM systems due to their exceptional brightness, photostability, sensitivity, and biocompatibility. However, Pdot glucose transducers are oxygen-dependent, and changes in tissue oxygen levels affect their measurement accuracy. Here, we describe an external ratiometric calibration method that corrects for changes in tissue oxygen levels to improve measurement accuracy. This method uses the ratio of oxygen concentrations inside and outside the Pdot glucose transducer as an indicator of glucose concentration to correct for signal deviations caused by tissue oxygen fluctuations. A second oxygen-sensitive Pdot that is not conjugated with glucose oxidase is used to measure the oxygen concentration outside the Pdot glucose transducer. We describe the theoretical basis for this approach and demonstrate its effectiveness experimentally in a subcutaneous mouse implant model. This external ratiometric system achieves higher accuracy glucose measurements than p
Who reads Improving the Accuracy of Pdot-Based Continuous Glucose Monitoring by Using External Ratiometric Calibration?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Kai Sun; Siyang Liu; Jing Liu; Zhaoyang Ding; Yifei Jiang; Jicheng Zhang; Haobin Chen; Jiangbo Yu; Changfeng Wu; Daniel T. Chiu
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)