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Oral Contraceptives Enhance The Risk Of Clinical Manifestation Of Venous Thrombosis At A Young Age In Females Homozygous For Factor V Leiden by Claudia Rintelen; Christine Mannhalter; Helen Ireland; David A. Lane; Paul Knöbl; Klaus Lechner; Ingrid Pabinger is a Medicine article available to read on EtoBox.

What is Oral Contraceptives Enhance The Risk Of Clinical Manifestation Of Venous Thrombosis At A Young Age In Females Homozygous For Factor V Leiden about?

In 29 patients (17 females) homozygous Arg 506 Gln mutation (FV Leiden) was identified. 25 had been investigated because of venous thromboembolism (VTE); four asymptomatic patients were found during family studies. The first VTE had occurred significantly earlier in females (median age [m] 26 years, range 17–49) than in males (m=38 years, range 21–82) (__P__ = 0.01). 12 females (80%) had taken oral contraceptives (OC, oestrogen content 0.02–0.1 mg) for 6–150 months prior to thrombosis. Further triggering conditions in females were hormone replacement (__n__ = 1) and pregnancy (__n__ = 2). In 8/10 males the first VTE had occurred spontaneously — in two after surgery. The sites of VTE were deep vein thrombosis, pulmonary embolism, caval vein thrombosis and superficial thrombophlebitis. From our data we conclude that OC medication is the most important precipitating factor for VTE in females with homozygous FV Leiden.

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Author

Claudia Rintelen; Christine Mannhalter; Helen Ireland; David A. Lane; Paul Knöbl; Klaus Lechner; Ingrid Pabinger

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

1996

Language

EN

Field

Medicine (Health Sciences)