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Efficacy and Safety of a Fixed Combination of 1% Brinzolamide and 0.1% Brimonidine as Treatment for Glaucoma: a Retrospective Study Focusing on the Number of Ingredients by Ryota Aoki; Etsuko Terao; Saki Dote; Miku Shiraishi; Satomi Oogi; Kanae Ueda; Yui Kimura; Yuki Nagata; Shunsuke Nakakura is a Medicine article available to read on EtoBox.
What is Efficacy and Safety of a Fixed Combination of 1% Brinzolamide and 0.1% Brimonidine as Treatment for Glaucoma: a Retrospective Study Focusing on the Number of Ingredients about?
## Objective To evaluate the intraocular pressure (IOP)-lowering effect based on the number of ingredients and survival rate due to adverse reactions of brinzolamide (1%)/brimonidine (0.1%) fixed combination (BBFC). ## Methods and analysis Among 424 patients newly administered BBFC from June 2020 to May 2021, 406 were retrospectively evaluated for adverse reactions and 299 were evaluated for the IOP-lowering effect of BBFC. Among those evaluated for IOP, group A (n=86) included patients whose treatment was changed to BBFC from other two ingredients, Group B (n=90) included patients who added one ingredient by switching to BBFC, and group C (n=123) included patients who added BBFC in addition to other drugs. ## Results The mean IOP (mm Hg) at BBFC initiation and at 3, 6 and 12 months after BBFC initiation was 14.1, 14.0, 14.3 and 13.8 in group A, 15.9, 14.4, 13.8 and 14.5 in group B and 17.2, 14.0, 14.1 and 14.9 in group C, respectively. Group A showed no significant difference in mean IOP from baseline to any time point after BBFC initiation, whereas groups B and C showed significant IOP reductions at all time points. Seventy-three (18%) patients discontinued treatment due to adver
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- Author
- Ryota Aoki; Etsuko Terao; Saki Dote; Miku Shiraishi; Satomi Oogi; Kanae Ueda; Yui Kimura; Yuki Nagata; Shunsuke Nakakura
- Publisher
- BMJ
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)