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Possible regulation of Wilms’ tumour gene 1 (WT1) expression by the paired box genes PAX2 and PAX8 and by the haematopoietic transcription factor GATA-1 in human acute myeloid leukaemias by Jan M. Siehl; Eckhard Thiel; Karin Heufelder; Emilian Snarski; Stefan Schwartz; Volker Mailänder; Ulrich Keilholz is a Medicine article available to read on EtoBox.
What is Possible regulation of Wilms’ tumour gene 1 (WT1) expression by the paired box genes PAX2 and PAX8 and by the haematopoietic transcription factor GATA-1 in human acute myeloid leukaemias about?
**Summary.** Overexpression of the embryonic transcription factor, Wilms’ tumour protein 1 (WT1), is common in acute myeloid leukaemias (AML). Mutations of Wilms’ tumour gene 1 (__WT1__) in AML are rare and __WT1__ expression may be increased by other transcription factors. __PAX2__, __PAX8__ and __GATA‐1__ are known physiological regulators of __WT1__. In the present study, we analysed either bone marrow or blood samples of 43 AML patients for the expression levels of __WT1__, __PAX2__, __PAX8__ and __GATA‐1__ by real‐time reverse transcription polymerase chain reaction (LightCycler). Bone marrow samples of patients without haematological malignancies and stem cell preparation samples from healthy donors and lymphoma patients served as controls. __PAX2__ expression was found in 11 of 43 AML samples, with a clear correlation of __PAX2__ with __WT1__ expression levels observed. __PAX8__ expression was found in two additional samples. __GATA‐1__ expression was detectable in 41 of 43 AML samples and also in all control samples; no significant differences between these groups were observed and no correlation of __GATA‐1__ expression with __WT1__ expression levels was apparent. In concl
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- Author
- Jan M. Siehl; Eckhard Thiel; Karin Heufelder; Emilian Snarski; Stefan Schwartz; Volker Mailänder; Ulrich Keilholz
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)