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Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists by Alan S. Florjancic; Sridhar Peddi; Arturo Perez-Medrano; Biqin Li; Marian T. Namovic; George Grayson; Diana L. Donnelly-Roberts; Michael F. Jarvis; William A. Carroll is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists about?
A novel series of aminotriazole-based P2X 7 antagonists was synthesized, and their structure-activity relationships (SAR) were investigated for activity at both human and rat P2X 7 receptors. Most compounds showed greater potency at the human receptor although several analogs were discovered with potent activity (pIC 50 P 7.5) at both human and rat P2X 7 .
Who reads Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Alan S. Florjancic; Sridhar Peddi; Arturo Perez-Medrano; Biqin Li; Marian T. Namovic; George Grayson; Diana L. Donnelly-Roberts; Michael F. Jarvis; William A. Carroll
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)