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The Acute Effects of Inhaled Salbutamol on the Beat‐to‐beat Variability of Heart Rate and Blood Pressure Assessed by Spectral Analysis by Tuomas Jartti; Timo Kaila; Kari Tahvanainen; Tom Kuusela; Timo Vanto; Ilkka Välimäki is a Medicine article available to read on EtoBox.
What is The Acute Effects of Inhaled Salbutamol on the Beat‐to‐beat Variability of Heart Rate and Blood Pressure Assessed by Spectral Analysis about?
__Aims__ We wanted to study the effects of a 600 μg inhaled salbutamol dose on the cardiovascular and respiratory autonomic nervous regulation in eight children suffering from bronchial asthma. __Methods__ In this randomized, double‐blind, placebo‐controlled, crossover study we continuously measured electrocardiogram, finger systolic arterial pressure (SAP) and flow‐volume spirometry at baseline as well as 20 min and 2 h after the drug inhalation. The R–R interval (the time between successive heart beats) and SAP variabilities were assessed by using spectral analysis. Baroreflex sensitivity was assessed by using cross‐spectral analysis. __Results__ Salbutamol significantly decreased the total and low frequency (LF) variability of R–R intervals as well as the high frequency (HF) variability of R–R intervals and of SAP. Salbutamol significantly increased the LF/HF ratio of R–R intervals and of SAP, minute ventilation, heart rate and forced pulmonary function in comparison with placebo. The weight of the subjects significantly correlated positively with baroreflex sensitivity and negatively with heart rate after the salbutamol inhalation. __Conclusions__ We conclude that the acute sal
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- Author
- Tuomas Jartti; Timo Kaila; Kari Tahvanainen; Tom Kuusela; Timo Vanto; Ilkka Välimäki
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)