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Prevention and Treatment of Tumor Lysis Syndrome in the Era of Onco-Nephrology Progress by Joanna Matuszkiewicz-Rowinska; Jolanta Malyszko is a Medicine article available to read on EtoBox.

What is Prevention and Treatment of Tumor Lysis Syndrome in the Era of Onco-Nephrology Progress about?

**__Background:__** Tumor lysis syndrome (TLS) is an oncologic emergency due to a rapid break down of malignant cells usually induced by cytotoxic therapy, with hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and serious clinical consequences such as acute renal injury, cardiac arrhythmia, hypotension, and death. Rapidly expanding knowledge of cancer immune evasion mechanisms and host-tumor interactions has significantly changed our therapeutic strategies in hemato-oncology what resulted in the expanding spectrum of neoplasms with a risk of TLS. **__Summary:__** Since clinical TLS is a life-threatening condition, identifying patients with risk factors for TLS development and implementation of adequate preventive measures remains the most critical component of its medical management. In general, these consist of vigilant laboratory and clinical monitoring, vigorous IV hydration, urate-lowering therapy, avoidance of exogenous potassium, use of phosphate binders, and – in high-risk cases – considering cytoreduction before the start of the aggressive agent or a gradual escalation of its dose. **__Key Messages:__** In patients with a high risk of TLS, cytotoxic chemotherap

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Author

Joanna Matuszkiewicz-Rowinska; Jolanta Malyszko

Publisher

S. Karger AG

Published

2020

Language

EN

Field

Medicine (Health Sciences)