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Can I read Aldehyde to Ketone Homologation Enabled by Improved Access to Thioalkyl Phosphonium Salts on EtoBox?
Aldehyde to Ketone Homologation Enabled by Improved Access to Thioalkyl Phosphonium Salts by Meghan Fragis; Jackson L. Deobald; Srinivas Dharavath; Jeffrey Scott; Jakob Magolan is a Chemistry article available to read on EtoBox.
What is Aldehyde to Ketone Homologation Enabled by Improved Access to Thioalkyl Phosphonium Salts about?
Phosphines were previously unusable as Pummerer-type nucleophiles due to competing redox chemistry with sulfoxides. Here we circumvent this problem to achieve a formal phosphine Pummerer reaction that offers thioalkyl phosphonium salts that, in turn, give rise to diverse vinyl sulfides via Wittig olefinations. Thirty vinyl sulfides are thus prepared from (alkylthioalkyl)triphenyl phosphonium salts and aldehydes. The hydrolysis of these vinyl sulfides offers an efficient and versatile two-step one-carbon homologation of aldehydes to ketones.
Who reads Aldehyde to Ketone Homologation Enabled by Improved Access to Thioalkyl Phosphonium Salts?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Meghan Fragis; Jackson L. Deobald; Srinivas Dharavath; Jeffrey Scott; Jakob Magolan
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)