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Novel Combination Therapy Against Metastatic and Androgen-independent Prostate Cancer by Using Gefitinib, Tamoxifen and Etoposide by Murielle Mimeault; Ganesh Venkatraman; Sonny L. Johansson; Erik Moore; Jean-Pierre Henichart; Patrick Depreux; Ming-Fong Lin; Surinder K. Batra is a Medicine article available to read on EtoBox.
What is Novel Combination Therapy Against Metastatic and Androgen-independent Prostate Cancer by Using Gefitinib, Tamoxifen and Etoposide about?
## Abstract In this study, we evaluated, for the first time, the antiproliferative and cytotoxic effects induced by a combination of a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, gefitinib, with other chemotherapeutic drugs including estrogen receptor‐beta (ER‐β) antagonist (tamoxifen) and topoisomerase II inhibitor (etoposide) on some metastatic prostate cancer (PC) cell lines. Immunohistochemial analyses revealed that EGFR expression was enhanced in 38% of primary prostatic adenocarcinomas (Gleason scores 4–10) as compared to the corresponding normal tissues of the same prostate gland from 32 PC patients. The RT‐PCR and Western blot data have also indicated the higher expression levels of EGFR and ER‐β transcripts and proteins in metastatic LNCaP, DU145 and PC3 cells relative to nonmalignant normal prostate cells. Moreover, the results from MTT and FACS analyses revealed that the drugs, alone or in combination at lower concentrations, inhibited the growth of 17β‐estradiol (E2) plus EGF and serum‐stimulated androgen‐responsive LNCaP‐C33 and androgen‐independent LNCaP‐C81, DU145 and PC3 cells. Importantly, the combined gefitinib, tamoxifen and etopo
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- Author
- Murielle Mimeault; Ganesh Venkatraman; Sonny L. Johansson; Erik Moore; Jean-Pierre Henichart; Patrick Depreux; Ming-Fong Lin; Surinder K. Batra
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)