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Pathogen-induced m6A dynamics affect plant immunity by Wil Prall; Arsheed H Sheikh; Jeremie Bazin; Jean Bigeard; Marilia Almeida-Trapp; Martin Crespi; Heribert Hirt; Brian D Gregory is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Pathogen-induced m6A dynamics affect plant immunity about?

## Abstract Post-transcriptional regulation of mRNA mediated by methylation at the N6 position of adenine (N6-methyladenosine (m6A)) has profound effects on transcriptome regulation in plants. Focused studies across eukaryotes offer glimpses into the processes governed by m6A throughout developmental and disease states. However, we lack an understanding of the dynamics and the regulatory potential of m6A during biotic stress in plants. Here, we provide a comprehensive look into the effects of m6A on both the short-term and long-term response to pathogen signaling in Arabidopsis (Arabidopsis thaliana). We demonstrate that m6A-deficient plants are more resistant to bacterial and fungal pathogen infections and have altered immune responses. Furthermore, m6A deposition is specifically coordinated on transcripts involved in defense and immunity prior to and proceeding the pathogen signal flagellin. Consequently, the dynamic modulation of m6A on specific stress-responsive transcripts is correlated with changes in abundance and cleavage of these transcripts. Overall, we show that the m6A methylome is regulated prior to and during simulated and active pathogen stress and functions in the c

Who reads Pathogen-induced m6A dynamics affect plant immunity?

Author

Wil Prall; Arsheed H Sheikh; Jeremie Bazin; Jean Bigeard; Marilia Almeida-Trapp; Martin Crespi; Heribert Hirt; Brian D Gregory

Publisher

Oxford University Press (OUP)

Published

2023

Field

Agricultural and Biological Sciences (Life Sciences)