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Inflammation‐Responsive Hydrogel Spray for Synergistic Prevention of Traumatic Heterotopic Ossification via Dual‐Homeostatic Modulation Strategy by Jiazhao Yang; Xudong Zhang; Baoliang Lu; Jiawei Mei; Lei Xu; Xianzuo Zhang; Zheng Su; Wei Xu; Shiyuan Fang; Chen Zhu; Dongdong Xu; Wanbo Zhu is a Engineering article available to read on EtoBox.
What is Inflammation‐Responsive Hydrogel Spray for Synergistic Prevention of Traumatic Heterotopic Ossification via Dual‐Homeostatic Modulation Strategy about?
## Abstract Traumatic heterotopic ossification (THO) represents one of the most prominent contributors to post‐traumatic joint dysfunction, which currently lacks an effective and definitive preventative approach. Inflammatory activation due to immune dyshomeostasis during the early stages of trauma is believed to be critical in initiating the THO disease process. This study proposes a dual‐homeostatic modulation (DHM) strategy to synergistically prevent THO without compromising normal trauma repair by maintaining immune homeostasis and inducing stem cell homeostasis. A methacrylate‐hyaluronic acid‐based hydrogel spray device encapsulating a curcumin‐loaded zeolitic imidazolate framework‐8@ceric oxide (ZIF‐8@CeO2, CZC) nanoparticles (CZCH) is designed. Photo‐crosslinked CZCH is used to form hydrogel films fleetly in periosteal soft tissues to achieve sustained curcumin and CeO2 nanoparticles release in response to acidity and reactive oxygen species (ROS) in the inflammatory microenvironment. In vitro experiments and RNA‐seq results demonstrated that CZCH achieved dual‐homeostatic regulation of inflammatory macrophages and stem cells through immune repolarization and enhanced effero
Who reads Inflammation‐Responsive Hydrogel Spray for Synergistic Prevention of Traumatic Heterotopic Ossification via Dual‐Homeostatic Modulation Strategy?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Jiazhao Yang; Xudong Zhang; Baoliang Lu; Jiawei Mei; Lei Xu; Xianzuo Zhang; Zheng Su; Wei Xu; Shiyuan Fang; Chen Zhu; Dongdong Xu; Wanbo Zhu
- Publisher
- Wiley
- Published
- 2023
- Field
- Engineering (Physical Sciences)