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97. The clinical implications of unbalanced CCND1::IGH rearrangement resulted from the 5′IGH deletion in multiple myeloma by Xinyan Lu; Amandeep Kaur; Barina Aqil; Juehua Gao; Madina Sukhanova; Yi-Hua Chen is a Medicine article available to read on EtoBox.

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Multiple myeloma (MM) is cytogenetically heterogeneous. IGH translocation driving the over expression of the fusion partner gene is considered as a primary genomic event in the pathogenesis of MM. Most IGH fusions in MM are balanced, however, unbalanced IGH fusions are frequent. While the unbalanced translocation resulted from the 3′IGH deletion has clinical implications, the 5′IGH deletion is not well studied and often could be interpreted as physiological event due to the IGH locus somatic V-D-J recombination. We retrospectively reviewed the FISH results from the clinical MM cases tested using the IGH breakapart and the dual fusion probe set CCND1-IGH. Immunohistochemistry (IHC) study to assess CCND1/BCL1 expression was performed. There were 142 cases with balanced CCND1::IGH, and 59 cases were unbalanced CCND1::IGH characterized by the 5′IGH deletion. The demographic and FISH data to assess hyperdiploidy, 1q gain, deletions of 1p, 13q and TP53 were comparable between these two groups. IHC also showed comparable CCND1/BCL1 overexpression in both groups. All patients were treated within the same institution, and the overall survival was comparable between the balanced and unbalanc

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Author

Xinyan Lu; Amandeep Kaur; Barina Aqil; Juehua Gao; Madina Sukhanova; Yi-Hua Chen

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)