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Can I read Association analysis in a Latin American population revealed ethnic differences in rheumatoid arthritis-associated SNPs in Caucasian and Asian populations on EtoBox?
Association analysis in a Latin American population revealed ethnic differences in rheumatoid arthritis-associated SNPs in Caucasian and Asian populations by Castro-Santos, P.; Verdugo, R. A.; Alonso-Arias, R.; Gutiérrez, M. A.; Suazo, J.; Aguillón, J. C.; Olloquequi, J.; Pinochet, C.; Lucia, A.; Quiñones, L. A.; Díaz-Peña, R. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Association analysis in a Latin American population revealed ethnic differences in rheumatoid arthritis-associated SNPs in Caucasian and Asian populations about?
Large genome-wide association studies (GWAS) have increased our knowledge of the genetic risk factors of rheumatoid arthritis (RA). However, little is known about genetic susceptibility in populations with a large admixture of Amerindian ancestry. The aim of the present study was to test the generalizability of previously reported RA __loci__ in a Latin American (LA) population with admixed ancestry. We selected 128 single nucleotide polymorphisms (SNPs) in linkage equilibrium, with high association to RA in multiple populations of non-Amerindian origin. Genotyping of 118 SNPs was performed in 313 RA patients/487 healthy control subjects by mid-density arrays of polymerase chain reaction (PCR). Some of the identified associations were validated in an additional cohort (250 cases/290 controls). One marker, the SNP rs2451258, located upstream of T Cell Activation RhoGTPase Activating Protein (__TAGAP__) gene, showed significant association with RA (p = 5 × 10^−3^), whereas 18 markers exhibited suggestive associations (p < 0.05). Haplotype testing showed association of some groups of adjacent SNPs around the signal transducer and activator of transcription 4 (__STAT4__) gene (p = 9.82
Who reads Association analysis in a Latin American population revealed ethnic differences in rheumatoid arthritis-associated SNPs in Caucasian and Asian populations?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Castro-Santos, P.; Verdugo, R. A.; Alonso-Arias, R.; Gutiérrez, M. A.; Suazo, J.; Aguillón, J. C.; Olloquequi, J.; Pinochet, C.; Lucia, A.; Quiñones, L. A.; Díaz-Peña, R.
- Publisher
- Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)