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The KiSS-1/GPR54 system: Essential roles in physiological homeostasis and cancer biology by Nisha Zhu; Mengxiang Zhao; Yuxian Song; Liang Ding; Yanhong Ni is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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__KiSS-1,__ first identified as an anti-metastasis gene in melanoma, encodes C-terminally amidated peptide products, including kisspeptin-145, kisspeptin-54, kisspeptin-14, kisspeptin-13 and kisspeptin-10. These products are endogenous ligands coupled to G protein-coupled receptor 54 (GPR54)/hOT7T175/AXOR12. To date, the regulatory activities of the KiSS-1/GPR54 system, such as puberty initiation, antitumor metastasis, fertility in adulthood, hypothalamic-pituitary-gonadal axis (HPG axis) feedback, and trophoblast invasion, have been investigated intensively. Accumulating evidence has demonstrated that __KiSS-1__ played a key role in reproduction and served as a promising biomarker relative to the diagnosis, identification of therapeutic targets and prognosis in various carcinomas, while few studies have systematically summarized its subjective factors and concluded the functions of KiSS-1/GPR54 signaling in physiology homeostasis and cancer biology. In this review, we retrospectively summarized the regulators of the KiSS-1/GPR54 system in different animal models and reviewed its functions according to physiological homeostasis regulations and above all, cancer biology, which provi

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Author

Nisha Zhu; Mengxiang Zhao; Yuxian Song; Liang Ding; Yanhong Ni

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)