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Can I read Protective effect of quercetin against 5-fluorouracil-induced cardiac impairments through activating Nrf2 and inhibiting NF-κB and caspase-3 activities on EtoBox?
Protective effect of quercetin against 5-fluorouracil-induced cardiac impairments through activating Nrf2 and inhibiting NF-κB and caspase-3 activities by Maha S. Lokman; Hussam A. Althagafi; Fahad Alharthi; Ola A. Habotta; Arwa A. Hassan; Mohamed A. Elhefny; Hassan Al Sberi; Abdulrahman Theyab; Ahmad Hasan Mufti; Alaa Alhazmi; Yousef M. Hawsawi; Asmaa F. Khafaga; Mahmoud S. Gewaily; Khalaf F. Alsharif; Ashraf Albrakati; Rami B. Kassab is a Environmental Science article available to read on EtoBox.
What is Protective effect of quercetin against 5-fluorouracil-induced cardiac impairments through activating Nrf2 and inhibiting NF-κB and caspase-3 activities about?
5-Fluorouracil (5-FU) is a chemotherapy used to treat many types of cancer. Cardiotoxicity is one of the common drawbacks of 5-FU therapy. Quercetin (Qu) is a bioflavonoid with striking biological activities. This research aimed to assess the ameliorative effect of Qu against 5-FU-mediated cardiotoxicity. Thirty-five rats were allocated into five groups: control group (normal saline), 5-FU group (30 mg/kg, intraperitoneally), Qu group (50 mg/kg, oral), 25 mg/kg Qu+5-FU group, and 50 mg/kg Qu+5-FU. The experimental animals were received the above-mentioned drugs for 21 days. Results showed that 5-FU significantly elevated creatine kinase, lactate dehydrogenase, serum cholesterol and triglyceride, and upregulated troponin and renin mRNA expression. Additionally, cardiac oxidant/antioxidant imbalance was evident in elevated oxidants (malondialdehyde and nitric oxide) and depleted antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione). 5-FU also downregulated the gene expression of nuclear factor erythroid 2-related factor 2. Furthermore, 5-FU significantly increased cardiac pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1 beta)
Who reads Protective effect of quercetin against 5-fluorouracil-induced cardiac impairments through activating Nrf2 and inhibiting NF-κB and caspase-3 activities?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Maha S. Lokman; Hussam A. Althagafi; Fahad Alharthi; Ola A. Habotta; Arwa A. Hassan; Mohamed A. Elhefny; Hassan Al Sberi; Abdulrahman Theyab; Ahmad Hasan Mufti; Alaa Alhazmi; Yousef M. Hawsawi; Asmaa F. Khafaga; Mahmoud S. Gewaily; Khalaf F. Alsharif; Ashraf Albrakati; Rami B. Kassab
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Environmental Science (Physical Sciences)