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High-protein Home Parenteral Nutrition in Malnourished Oncology Patients: a Systematic Literature Review by Paolo Cotogni; Clare Shaw; Paula Jimenez-Fonseca; Dominic Partridge; David Pritchett; Neil Webb; Amy Crompton; Pilar Garcia-Lorda; Julian Shepelev is a Medicine article available to read on EtoBox.
What is High-protein Home Parenteral Nutrition in Malnourished Oncology Patients: a Systematic Literature Review about?
## Introduction Up to 83% of oncology patients are affected by cancer-related malnutrition, depending on tumour location and patient age. Parenteral nutrition can be used to manage malnutrition, but there is no clear consensus as to the optimal protein dosage. The objective of this systematic literature review (SLR) was to identify studies on malnourished oncology patients receiving home parenteral nutrition (HPN) where protein or amino acid delivery was reported in g/kg bodyweight/day, and to compare outcomes between patients receiving low ( 1.5 g/kg/day). ## Methods Literature searches were performed on 5^th^ October 2021 in Embase, MEDLINE, and five Cochrane Library and Centre for Reviews and Dissemination databases. Searches were complemented by hand-searching of conference proceedings, a clinical trial registry, and bibliographic reference lists of included studies and relevant SLRs/meta-analyses. ## Results Nineteen publications were included; sixteen investigated standard protein, two reported low protein, and one included both, but none assessed high-protein doses. Only one randomised controlled trial (RCT) was identified; all other studies were observational studies. The
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- Author
- Paolo Cotogni; Clare Shaw; Paula Jimenez-Fonseca; Dominic Partridge; David Pritchett; Neil Webb; Amy Crompton; Pilar Garcia-Lorda; Julian Shepelev
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)