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What is Fibrinolytic Therapy Failures in Empyema about?
The correspondence discusses the role of neutrophil elastase and plasminogen activator inhibitor 1 (PAI-1) in the failure of fibrinolytic therapy for empyema. The authors argue for the need for prospective clinical trials to evaluate the contributions of plasminogen degradation and PAI-1 levels to treatment outcomes. They emphasize the importance of understanding the dynamics of PAI-1 activity and its implications for the efficacy of intrapleural lytics.
- Author
- Tatan Quintero
- Language
- EN