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Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children—Correlation with Interleukin-4, Interleukin-5, and Interleukin-21 by Mohammed Saeed Al-Ayed; Khaled Sadeq Al-Shaibari; Dhafer Alshehri; Mohammed Jamaan Alzahrani; Iman Nasser; Hamdan Saad Alaamri; Wed Ahmad Alaseeri; Ahmed A. Mahfouz; Saeed Ali Alsareii; Ahmed Morad Asaad; Aamir Magzoub; Mohammed Ansar Qureshi; Ehab Elagab; Elhashimi Eltayb Hassan; Mohammed Helmy Faris Shalayel is a Medicine article available to read on EtoBox.

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Ghrelin is a peptide hormone with direct or indirect effects on obesity and asthma. More data are required to understand the effect of ghrelin on the control and pathogenesis of these diseases. The aim of this study was to evaluate ghrelin levels in selected groups of children to identify the association between serum ghrelin, obesity, and the severity of asthma. The study included 401 school children selected from the Najran area and grouped into non-obese asthmatics, obese asthmatics, obese non-asthmatics and controls (non-obese non-asthmatics). Blood levels of ghrelin, interleukin (IL)-4, IL-5 and IL-21 were determined by ELISA. The mean ghrelin values were insignificantly increased in obese children compared with non-obese children. The highest blood ghrelin values were in the non-obese asthmatic group. Serum ghrelin, IL-4 and IL-21 levels were significantly increased in asthmatic children compared with non-asthmatic children (__p__ < 0.05), and there were significant positive correlations between ghrelin and IL-4, IL-5, and IL-21 in asthmatic children. Furthermore, ghrelin, IL-4, and IL-21 levels were significantly higher in uncontrolled asthmatics compared with controlled-ast

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Author

Mohammed Saeed Al-Ayed; Khaled Sadeq Al-Shaibari; Dhafer Alshehri; Mohammed Jamaan Alzahrani; Iman Nasser; Hamdan Saad Alaamri; Wed Ahmad Alaseeri; Ahmed A. Mahfouz; Saeed Ali Alsareii; Ahmed Morad Asaad; Aamir Magzoub; Mohammed Ansar Qureshi; Ehab Elagab; Elhashimi Eltayb Hassan; Mohammed Helmy Faris Shalayel

Publisher

MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI, 2003-; ScienceOpen (ISSN 1660-4601)

Published

2020

Language

EN

Field

Medicine (Health Sciences)