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The p38MAPK-MK2 Signaling Axis as a Critical Link Between Inflammation and Synaptic Transmission by Edward Beamer; Sonia A. L. Corrêa is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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p38 is a mitogen-activated protein kinase (MAPK), that responds primarily to stress stimuli. p38 has a number of targets for phosphorylation, including MAPK-activated protein kinase 2 (MK2). MK2 primarily functions as a master regulator of RNA-binding proteins, indirectly controlling gene expression at the level of translation. The role of MK2 in regulating the synthesis of pro-inflammatory cytokines downstream of inflammation and cellular stress is well-described. A significant amount of evidence, however, now points to a role for the p38^MAPK^-MK2 signaling axis in mediating synaptic plasticity through control of AMPA receptor trafficking and the morphology of dendritic spines. These processes are mediated through control of cytoskeletal dynamics via the activation of cofilin-1 and possibly control of the expression of Arc/Arg3.1. There is evidence that MK2 is necessary for group I metabotropic glutamate receptors long-term depression (mGluR-LTD). Disruption of this signaling may play an important role in mediating cognitive dysfunction in neurological disorders such as fragile X syndrome and Alzheimer’s disease. To date, the role of neuronal MK2 mediating synaptic plasticity in

Who reads The p38MAPK-MK2 Signaling Axis as a Critical Link Between Inflammation and Synaptic Transmission?

Author

Edward Beamer; Sonia A. L. Corrêa

Publisher

Frontiers Media SA

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)