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Association between serum pepsinogens and polymorphismof PTPN11 encoding SHP‐2 among Helicobacter pylori seropositive Japanese by Yasuyuki Goto; Takafumi Ando; Kazuhito Yamamoto; Akiko Tamakoshi; Emad El‐Omar; Hidemi Goto; Nobuyuki Hamajima is a Medicine article available to read on EtoBox.

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## Abstract __Helicobacter pylori__ (__H. pylori__) plays a crucial role in the development of gastric atrophy and cancer, and __cagA__‐positive strains, which are universal in Japan, increase the risk of these outcomes substantially. The CagA protein is injected from attached __H. pylori__ into gastric epithelial cells and undergoes Src‐dependent tyrosine phosphorylation and activation of the eukaryotic phosphatase SHP‐2. The CagA/SHP‐2 interactions elicit cellular changes that increase the risk of carcinogenesis. We investigated the association of a frequent single nucleotide polymorphism (SNP; JST057927; G‐to‐A) in the __PTPN11__ gene that encodes SHP‐2 with gastric atrophy and gastric cancer in Japan. Gastric atrophy was assessed by measuring serum pepsinogen I and II levels. The subjects comprised 454 healthy controls (126 males; mean age, 58.4) and 202 gastric cancer cases (134 males and 68 females; mean age, 66.7). All gastric cancer cases and 250 (55%) controls were __H. pylori__ seropositive; 179 (89%) of the gastric cancer cases had gastric atrophy compared to 137 (55%) of the __H. pylori__ seropositive controls (__p__ < 0.001). Among __HP__ seropositive controls compared

Who reads Association between serum pepsinogens and polymorphismof PTPN11 encoding SHP‐2 among Helicobacter pylori seropositive Japanese?

Author

Yasuyuki Goto; Takafumi Ando; Kazuhito Yamamoto; Akiko Tamakoshi; Emad El‐Omar; Hidemi Goto; Nobuyuki Hamajima

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2005

Language

EN

Field

Medicine (Health Sciences)