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Association of angiotensin I converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms with breast cancer prognostic factors in iranian population by Soha Namazi; Ahmad Monabati; Shirin Ardeshir‐Rouhani‐Fard; Negar Azarpira is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract It has been indicated that renin‐angiotensin system (RAS) has role in various steps of cancer progression. The presence of RAS components has been shown in normal and breast cancer tissue. Insertion/Deletion (I/D) is one of angiotensin I converting enzyme (ACE) polymorphisms and A1166C is one of Angiotensin II type‐1 receptor (AT1R) polymorphisms which have been associated with various diseases such as cardiovascular diseases. In the present study, we aimed to substantiate the putative significance of ACE and AT1R on breast cancer biology by investigating the influence of their gene polymorphisms on breast cancer progression. The I/D and A1166C polymorphisms were evaluated by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP), respectively in 70 breast cancer patients diagnosed with invasive breast cancer and 70 healthy women. Breast cancer prognostic factors were obtained from medical and pathology reports of patients. There was no significant difference between cases and controls for ACE (I/D) (__P__ = 0.15) and AT1R (A1166C) genotypes (__P__ = 0.86). In breast cancer patients, when __DD__ genotype was used as reference group, th

Who reads Association of angiotensin I converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms with breast cancer prognostic factors in iranian population?

Author

Soha Namazi; Ahmad Monabati; Shirin Ardeshir‐Rouhani‐Fard; Negar Azarpira

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)